Fluid shear stress activates YAP1 to promote cancer cell motility

Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid...

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Detalles Bibliográficos
Autores principales: Lee, Hyun Jung, Diaz, Miguel F., Price, Katherine M., Ozuna, Joyce A., Zhang, Songlin, Sevick-Muraca, Eva M., Hagan, John P., Wenzel, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253685/
https://www.ncbi.nlm.nih.gov/pubmed/28098159
http://dx.doi.org/10.1038/ncomms14122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253685/
https://www.ncbi.nlm.nih.gov/pubmed/28098159
http://dx.doi.org/10.1038/ncomms14122

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