Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer

Traditional studies have shown that transcription factors, including SOX-2, OCT-4, KLF-4, Nanog and Lin-28A, contribute to the dedifferentiation and reprogramming process in normal tissues. Hypoxia is a physiological phenomenon that exists in tumors and promotes the expression of SOX-2, OCT-4, KLF-4...

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Detalles Bibliográficos
Autores principales: Wang, Pan, Wan, Wen-wu, Xiong, Shuang-Long, Feng, Hua, Wu, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253691/
https://www.ncbi.nlm.nih.gov/pubmed/28179999
http://dx.doi.org/10.1038/cddiscovery.2016.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253691/
https://www.ncbi.nlm.nih.gov/pubmed/28179999
http://dx.doi.org/10.1038/cddiscovery.2016.105

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