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α3 Chains of type V collagen regulate breast tumour growth via glypican-1
Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary tumour model inhibits mammary tumour progression by reduc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253704/ https://www.ncbi.nlm.nih.gov/pubmed/28102194 http://dx.doi.org/10.1038/ncomms14351 |
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author | Huang, Guorui Ge, Gaoxiang Izzi, Valerio Greenspan, Daniel S. |
author_facet | Huang, Guorui Ge, Gaoxiang Izzi, Valerio Greenspan, Daniel S. |
author_sort | Huang, Guorui |
collection | PubMed |
description | Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary tumour model inhibits mammary tumour progression by reducing the proliferative potential of tumour cells. These effects are shown to be primarily cell autonomous, from loss of α3(V) chains normally produced by tumour cells, in which they affect growth by enhancing the ability of cell surface proteoglycan glypican-1 to act as a co-receptor for FGF2. Thus, a mechanism is presented for microenvironmental influence on tumour growth. α3(V) chains are produced in both basal-like and luminal human breast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast cancer types. Evidence indicates α3(V) chains as potential targets for inhibiting tumour growth and as markers of oncogenic transformation. |
format | Online Article Text |
id | pubmed-5253704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52537042017-02-03 α3 Chains of type V collagen regulate breast tumour growth via glypican-1 Huang, Guorui Ge, Gaoxiang Izzi, Valerio Greenspan, Daniel S. Nat Commun Article Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary tumour model inhibits mammary tumour progression by reducing the proliferative potential of tumour cells. These effects are shown to be primarily cell autonomous, from loss of α3(V) chains normally produced by tumour cells, in which they affect growth by enhancing the ability of cell surface proteoglycan glypican-1 to act as a co-receptor for FGF2. Thus, a mechanism is presented for microenvironmental influence on tumour growth. α3(V) chains are produced in both basal-like and luminal human breast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast cancer types. Evidence indicates α3(V) chains as potential targets for inhibiting tumour growth and as markers of oncogenic transformation. Nature Publishing Group 2017-01-19 /pmc/articles/PMC5253704/ /pubmed/28102194 http://dx.doi.org/10.1038/ncomms14351 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Huang, Guorui Ge, Gaoxiang Izzi, Valerio Greenspan, Daniel S. α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title | α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title_full | α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title_fullStr | α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title_full_unstemmed | α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title_short | α3 Chains of type V collagen regulate breast tumour growth via glypican-1 |
title_sort | α3 chains of type v collagen regulate breast tumour growth via glypican-1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253704/ https://www.ncbi.nlm.nih.gov/pubmed/28102194 http://dx.doi.org/10.1038/ncomms14351 |
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