Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature

PURPOSE: To investigate whether Epac1 is key to Compound 49b's regulation of zonula occluden 1 (ZO-1) and occludin levels in human retinal endothelial cells (REC) and in an Epac1 vascular-specific conditional knockout mouse retina. METHODS: Primary REC were grown in normal (5 mM) or high glucos...

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Detalles Bibliográficos
Autores principales: Jiang, Youde, Liu, Li, Steinle, Jena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256679/
https://www.ncbi.nlm.nih.gov/pubmed/28114578
http://dx.doi.org/10.1167/iovs.16-20412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256679/
https://www.ncbi.nlm.nih.gov/pubmed/28114578
http://dx.doi.org/10.1167/iovs.16-20412

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