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Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy

PURPOSE: To determine cellular and temporal expression patterns of herpes virus entry mediator (HVEM, Tnfrsf14) in the murine cornea during the course of herpes simplex virus 1 (HSV-1) infection, the impact of this expression on pathogenesis, and whether alterations in HVEM or downstream HVEM-mediat...

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Detalles Bibliográficos
Autores principales: Edwards, Rebecca G., Kopp, Sarah J., Ifergan, Igal, Shui, Jr-Wen, Kronenberg, Mitchell, Miller, Stephen D., Longnecker, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256684/
https://www.ncbi.nlm.nih.gov/pubmed/28114589
http://dx.doi.org/10.1167/iovs.16-20668