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Low Expression in Xenopus Oocytes and Unusual Functional Properties of α(1)β(2)γ(2) GABA(A) Receptors with Non-Conventional Subunit Arrangement

The major subunit isoform of GABA(A) receptors is α(1)β(2)γ(2). The subunits are thought to surround an ion pore with the counterclockwise arrangement α(1)γ(2)β(2)α(1)β(2) as seen from the outside of the neuron. These receptors have two agonist sites and one high affinity drug binding site specific...

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Detalles Bibliográficos
Autores principales: Baur, Roland, Sigel, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256883/
https://www.ncbi.nlm.nih.gov/pubmed/28114407
http://dx.doi.org/10.1371/journal.pone.0170572

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