Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR). Expression of polyglutamine-expanded AR causes damage to motor neurons and skele...

Descripción completa

Detalles Bibliográficos
Autores principales: Milioto, Carmelo, Malena, Adriana, Maino, Eleonora, Polanco, Maria J., Marchioretti, Caterina, Borgia, Doriana, Pereira, Marcelo Gomes, Blaauw, Bert, Lieberman, Andrew P., Venturini, Roberta, Plebani, Mario, Sambataro, Fabio, Vergani, Lodovica, Pegoraro, Elena, Sorarù, Gianni, Pennuto, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259768/
https://www.ncbi.nlm.nih.gov/pubmed/28117338
http://dx.doi.org/10.1038/srep41046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259768/
https://www.ncbi.nlm.nih.gov/pubmed/28117338
http://dx.doi.org/10.1038/srep41046

Ejemplares similares