A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk

Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. This phenomenon allows for selecting a limited number of SNPs from GWAS repositories for large-scale studies investigating s...

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Detalles Bibliográficos
Autores principales: Elands, Rachel J. J., Simons, Colinda C. J. M., Riemenschneider, Mona, Isaacs, Aaron, Schouten, Leo J., Verhage, Bas A., Van Steen, Kristel, Godschalk, Roger W. L., van den Brandt, Piet A., Stoll, Monika, Weijenberg, Matty P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259777/
https://www.ncbi.nlm.nih.gov/pubmed/28117334
http://dx.doi.org/10.1038/srep41034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259777/
https://www.ncbi.nlm.nih.gov/pubmed/28117334
http://dx.doi.org/10.1038/srep41034

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