Cargando…

Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance

BACKGROUND: Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a cocktail of inhibitors targeting key viral enzymes. Numerous new drugs have been developed over the past few decades but viral re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Chinh Tran-To, Ling, Wei-Li, Lua, Wai-Heng, Haw, Yu-Xuan, Gan, Samuel Ken-En
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259968/ https://www.ncbi.nlm.nih.gov/pubmed/28155724 http://dx.doi.org/10.1186/s12859-016-1372-3

Ejemplares similares

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs
por: Su, Chinh Tran-To, et al.
Publicado: (2019)

Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding
por: Su, Chinh Tran-To, et al.
Publicado: (2018)

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance
por: Yeo, Joshua Yi, et al.
Publicado: (2020)

The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding
por: Su, Chinh Tran-To, et al.
Publicado: (2017)

Molecular Insights of Nickel Binding to Therapeutic Antibodies as a Possible New Antibody Superantigen
por: Su, Chinh Tran-To, et al.
Publicado: (2021)

Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance
por: Babrzadeh, Farbod, et al.
Publicado: (2013)

Spectrum of Atazanavir-Selected Protease Inhibitor-Resistance Mutations
por: Rhee, Soo-Yon, et al.
Publicado: (2022)

Essentially Leading Antibody Production: An Investigation of Amino Acids, Myeloma, and Natural V-Region Signal Peptides in Producing Pertuzumab and Trastuzumab Variants
por: Ling, Wei-Li, et al.
Publicado: (2020)

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
por: Zeminian, Luciana Bonome, et al.
Publicado: (2013)

Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease
por: Flynn, William F., et al.
Publicado: (2015)

Development of Elvitegravir Resistance and Linkage of Integrase Inhibitor Mutations with Protease and Reverse Transcriptase Resistance Mutations
por: Winters, Mark A., et al.
Publicado: (2012)

Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors
por: Codoñer, Francisco M, et al.
Publicado: (2017)

Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it
por: Lua, Wai-Heng, et al.
Publicado: (2017)

Fast reversible single-step method for enhanced band contrast of polyacrylamide gels for automated detection
por: Ling, Wei-Li, et al.
Publicado: (2015)

Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
por: Ling, Wei-Li, et al.
Publicado: (2020)

Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L
por: Ling, Wei-Li, et al.
Publicado: (2022)

Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease
por: Laville, Pierre, et al.
Publicado: (2020)

Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease
por: Laville, Pierre, et al.
Publicado: (2021)

Analysis of drug resistance in HIV protease
por: Pawar, Shrikant D., et al.
Publicado: (2018)

Protease‐resistant streptavidin for interaction proteomics
por: Rafiee, Mahmoud‐Reza, et al.
Publicado: (2020)

Evolution of drug resistance in HIV protease
por: Shah, Dhara, et al.
Publicado: (2020)

Potential Elucidation of a Novel CTL Epitope in HIV-1 Protease by the Protease Inhibitor Resistance Mutation L90M
por: Smidt, Werner
Publicado: (2013)

Allelic Origin of Protease-Sensitive and Protease-Resistant Prion Protein Isoforms in Gerstmann-Sträussler-Scheinker Disease with the P102L Mutation
por: Monaco, Salvatore, et al.
Publicado: (2012)

Identification of HCV protease inhibitor resistance mutations by selection pressure-based method
por: Qiu, Ping, et al.
Publicado: (2009)

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
por: Cai, Yufeng, et al.
Publicado: (2014)

Resistance associated mutations to protease inhibitors on HIV-2 infected patients in Portugal
por: Lopes, J., et al.
Publicado: (2021)

Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types
por: Yeo, Joshua Yi, et al.
Publicado: (2020)

A19 Genetic markers for protease inhibitor drug resistance in regions outside of the protease gene
por: Giandhari, J., et al.
Publicado: (2017)

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web
por: Fortelny, Nikolaus, et al.
Publicado: (2014)

Role of Gag in HIV Resistance to Protease Inhibitors
por: Clavel, François, et al.
Publicado: (2010)

Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease
por: Mótyán, János András, et al.
Publicado: (2022)

Naturally-occurring hepatitis C virus protease variants: implications for resistance to new antivirals
por: López-Labrador, F.X., et al.
Publicado: (2006)

A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2
por: Lua, Wai-Heng, et al.
Publicado: (2015)

An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition of Wild-Type and Drug-Resistant Proteases
por: Ung, Peter M.-U., et al.
Publicado: (2014)

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
por: Bastys, Tomas, et al.
Publicado: (2020)

Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients
por: Kapoor, Amit, et al.
Publicado: (2008)

Prevalence of drug resistance mutations in HIV-1 protease gene from North India
por: Azam, Mohd, et al.
Publicado: (2012)

A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
por: Dickinson, Bryan C., et al.
Publicado: (2014)

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
por: de Wispelaere, Mélissanne, et al.
Publicado: (2019)

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease
por: Zhang, Tian-hao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_djrt73r33t31ctmug6l546fod3