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Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs
BACKGROUND: Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259988/ https://www.ncbi.nlm.nih.gov/pubmed/28155702 http://dx.doi.org/10.1186/s12859-016-1374-1 |