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Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs

BACKGROUND: Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus...

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Detalles Bibliográficos
Autores principales:	Dholakia, Dhwani, Goyal, Sukriti, Jamal, Salma, Singh, Aditi, Das, Asmita, Grover, Abhinav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259988/ https://www.ncbi.nlm.nih.gov/pubmed/28155702 http://dx.doi.org/10.1186/s12859-016-1374-1

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