Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents

BACKGROUND: Tar DNA binding protein 43 (TDP-43) hyperphosphorylation, caused by Casein kinase 1 (CK-1) protein isoforms, is associated with the onset and progression of Amyotrophic Lateral Sclerosis (ALS). Among the reported isoforms and splice variants of CK-1 protein superfamily, CK-1δ is known to...

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Detalles Bibliográficos
Autores principales: Joshi, Kopal, Goyal, Sukriti, Grover, Sonam, Jamal, Salma, Singh, Aditi, Dhar, Pawan, Grover, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260052/
https://www.ncbi.nlm.nih.gov/pubmed/28155653
http://dx.doi.org/10.1186/s12859-016-1379-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260052/
https://www.ncbi.nlm.nih.gov/pubmed/28155653
http://dx.doi.org/10.1186/s12859-016-1379-9

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