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Exploiting the recognition code for elucidating the mechanism of zinc finger protein-DNA interactions
BACKGROUND: Engineering zinc finger protein motifs for specific binding to double-stranded DNA is critical for targeted genome editing. Most existing tools for predicting DNA-binding specificity in zinc fingers are trained on data obtained from naturally occurring proteins, thereby skewing the predi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260074/ https://www.ncbi.nlm.nih.gov/pubmed/28155654 http://dx.doi.org/10.1186/s12864-016-3324-8 |