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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in cluste...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260099/ https://www.ncbi.nlm.nih.gov/pubmed/28115009 http://dx.doi.org/10.1186/s13073-016-0393-x |