Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

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The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a r...

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Detalles Bibliográficos
Autores principales: Delgado-Camprubi, Marta, Esteras, Noemi, Soutar, Marc PM, Plun-Favreau, Helene, Abramov, Andrey Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260490/
https://www.ncbi.nlm.nih.gov/pubmed/27689878
http://dx.doi.org/10.1038/cdd.2016.104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260490/
https://www.ncbi.nlm.nih.gov/pubmed/27689878
http://dx.doi.org/10.1038/cdd.2016.104

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