Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population

AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsy...

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Autores principales: Suzuki, Kazushi, Koide, Daisuke, Fujii, Kurumi, Yamazaki, Tsutomu, Tsuji, Shoji, Iwata, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260534/
https://www.ncbi.nlm.nih.gov/pubmed/28203247
http://dx.doi.org/10.1159/000454660
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author Suzuki, Kazushi
Koide, Daisuke
Fujii, Kurumi
Yamazaki, Tsutomu
Tsuji, Shoji
Iwata, Atsushi
author_facet Suzuki, Kazushi
Koide, Daisuke
Fujii, Kurumi
Yamazaki, Tsutomu
Tsuji, Shoji
Iwata, Atsushi
author_sort Suzuki, Kazushi
collection PubMed
description AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. PATIENTS: Overall, 64 participants were diagnosed with cognitive deterioration. To control for the effect of sex differences, 2 independent sets of single-variable and multivariate logistic regression analyses were performed with quartiles divided into non-sex-specific and sex-specific cutoff values for UA. RESULTS: In non-sex-specific quartiles, the participants in the highest quartiles of UA levels were found to be at a significantly higher risk of cognitive deterioration than those in the lowest quartiles. In sex-specific quartiles, the highest quartile showed an increased risk of cognitive deterioration, and a greater than fourfold increase in the risk in the highest quartiles was confirmed using multivariate regression models. However, no significant association was observed between serum UA levels and the presence of white matter lesions. CONCLUSIONS: Elevated serum UA levels were independently associated with cognitive deterioration. UA might have unknown adverse effects on cognitive function, other than causing vascular pathology.
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spelling pubmed-52605342017-02-15 Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population Suzuki, Kazushi Koide, Daisuke Fujii, Kurumi Yamazaki, Tsutomu Tsuji, Shoji Iwata, Atsushi Dement Geriatr Cogn Dis Extra Original Research Article AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. PATIENTS: Overall, 64 participants were diagnosed with cognitive deterioration. To control for the effect of sex differences, 2 independent sets of single-variable and multivariate logistic regression analyses were performed with quartiles divided into non-sex-specific and sex-specific cutoff values for UA. RESULTS: In non-sex-specific quartiles, the participants in the highest quartiles of UA levels were found to be at a significantly higher risk of cognitive deterioration than those in the lowest quartiles. In sex-specific quartiles, the highest quartile showed an increased risk of cognitive deterioration, and a greater than fourfold increase in the risk in the highest quartiles was confirmed using multivariate regression models. However, no significant association was observed between serum UA levels and the presence of white matter lesions. CONCLUSIONS: Elevated serum UA levels were independently associated with cognitive deterioration. UA might have unknown adverse effects on cognitive function, other than causing vascular pathology. S. Karger AG 2016-12-22 /pmc/articles/PMC5260534/ /pubmed/28203247 http://dx.doi.org/10.1159/000454660 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
spellingShingle Original Research Article
Suzuki, Kazushi
Koide, Daisuke
Fujii, Kurumi
Yamazaki, Tsutomu
Tsuji, Shoji
Iwata, Atsushi
Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title_full Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title_fullStr Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title_full_unstemmed Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title_short Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population
title_sort elevated serum uric acid levels are related to cognitive deterioration in an elderly japanese population
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260534/
https://www.ncbi.nlm.nih.gov/pubmed/28203247
http://dx.doi.org/10.1159/000454660
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