Cargando…

The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling

Among all tissues and organs, the mammary gland is unique because most of its development occurs in adulthood. Notch signaling has a major role in mammary gland development and has been implicated in breast cancer. The vacuolar-ATPase (V-ATPase) is a proton pump responsible for the regulation and co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pamarthy, Sahithi, Mao, Liquin, Katara, Gajendra K, Fleetwood, Sara, Kulshreshta, Arpita, Gilman-Sachs, Alice, Beaman, Kenneth D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260869/ https://www.ncbi.nlm.nih.gov/pubmed/27809299 http://dx.doi.org/10.1038/cddis.2016.347

Ejemplares similares

The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells
por: Pamarthy, Sahithi, et al.
Publicado: (2015)

Vacuolar ATPase ‘a2’ isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer
por: Kulshrestha, Arpita, et al.
Publicado: (2015)

Mammary epithelium‐specific inactivation of V‐ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer
por: Katara, Gajendra K., et al.
Publicado: (2017)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

Notch Signaling in Inflammation-Induced Preterm Labor
por: Jaiswal, Mukesh K., et al.
Publicado: (2015)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8
por: Ibrahim, Safaa A., et al.
Publicado: (2016)

In vivo anti‐V‐ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses
por: Kulshrestha, Arpita, et al.
Publicado: (2020)

Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression
por: Ibrahim, Safaa A., et al.
Publicado: (2015)

Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells
por: Sahoo, Manoranjan, et al.
Publicado: (2018)

Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils
por: Ibrahim, Safaa A., et al.
Publicado: (2020)

Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway
por: Kulshrestha, Arpita, et al.
Publicado: (2019)

An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase
por: Kwong, Christina, et al.
Publicado: (2013)

Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor
por: Agrawal, Varkha, et al.
Publicado: (2015)

Interleukin‐22 promotes development of malignant lesions in a mouse model of spontaneous breast cancer
por: Katara, Gajendra K., et al.
Publicado: (2019)

Expression of a2 Vacuolar ATPase in Spermatozoa is Associated with Semen Quality and Chemokine-Cytokine Profiles in Infertile Men
por: Ota, Kuniaki, et al.
Publicado: (2013)

Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells
por: Kulshrestha, Arpita, et al.
Publicado: (2017)

The Notch system during pubertal development of the bovine mammary gland
por: Bonadeo, Nadia, et al.
Publicado: (2019)

The bovine mammary gland expresses multiple functional isoforms of serotonin receptors
por: Hernandez, Laura L, et al.
Publicado: (2009)

Patient derived organoids in prostate cancer: improving therapeutic efficacy in precision medicine
por: Pamarthy, Sahithi, et al.
Publicado: (2021)

Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox
por: Guo, Qiuchen, et al.
Publicado: (2017)

A Role for Iodide and Thyroglobulin in Modulating the Function of Human Immune Cells
por: Bilal, Mahmood Y., et al.
Publicado: (2017)

Tumors of the mammary gland
por: Rosen, Paul Peter
Publicado: (1993)

Mammary gland neoplasia.
por: Neumann, D A, et al.
Publicado: (1996)

Tuberculosis of the Mammary Gland
por: Goyle, Amar Nath, et al.
Publicado: (1935)

Tumor in Mammary Gland
Publicado: (1872)

Immunohistochemical expression of TGFβ, E-cadherin and vimentin in benign and malignant neoplasias of canine mammary gland
por: Terra, Erika M, et al.
Publicado: (2013)

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland
por: Kohn, Ethan A, et al.
Publicado: (2010)

The vacuolar-ATPase (V-ATPase) modulates matrix metalloproteinase (MMP) isoforms in human pancreatic cancer
por: Chung, Chuhan, et al.
Publicado: (2011)

Mammary stem cells: angels or demons in mammary gland?
por: Chen, Xueman, et al.
Publicado: (2017)

Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveals isoform-specific roles in mammary gland development and carcinogenesis
por: Wali, Vikram B, et al.
Publicado: (2014)

Surgical Pathology of the Mammary Gland
Publicado: (1934)

Epigenomics of mammary gland development
por: Holliday, Holly, et al.
Publicado: (2018)

Carcinoma of the Male Mammary Gland
por: Beatson, George Thos.
Publicado: (1911)

Engineering Immunity in the Mammary Gland
por: Kolb, Andreas F.
Publicado: (2002)

Extraordinary Development of the Mammary Glands
Publicado: (1858)

Acute Hyperthrophy of the Mammary Glands
por: Crofford, T. J.
Publicado: (1891)

Excision of a Mammary Gland
por: Martin, W. J.
Publicado: (1896)

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells
por: Arase, Mayu, et al.
Publicado: (2017)

Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland
por: Hens, Julie R, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_74u7l8e313ledn4o8p5ul08a9e