De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II

The transforming growth factor β-1 (TGFβ-1) signaling pathway plays a central role in the pathogenesis of pulmonary fibrosis. Two TGFβ-1 receptors, TβRI and TβRII, mediate this pathway. TβRI protein stability, as mediated by the ubiquitin/de-ubiquitination system, has been well studied; however, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacko, A M, Nan, L, Li, S, Tan, J, Zhao, J, Kass, D J, Zhao, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260874/
https://www.ncbi.nlm.nih.gov/pubmed/27853171
http://dx.doi.org/10.1038/cddis.2016.371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260874/
https://www.ncbi.nlm.nih.gov/pubmed/27853171
http://dx.doi.org/10.1038/cddis.2016.371

Ejemplares similares