EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

Lidamycin (LDM) is a novel member of the enediyne antibiotics identified in China with potent antitumor activity. However, it remains unclear whether LDM has potential molecular targets that may affect its antitumor activity. Enhancer of zeste homolog 2 (EZH2) functions as a histone lysine methyltra...

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Detalles Bibliográficos
Autores principales: Sha, Ming-Quan, Zhao, Xiao-Li, Li, Liang, Li, Li-Hui, Li, Yi, Dong, Tian-Geng, Niu, Wei-Xin, Jia, Li-Jun, Shao, Rong-Guang, Zhen, Yong-Su, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260875/
https://www.ncbi.nlm.nih.gov/pubmed/27882937
http://dx.doi.org/10.1038/cddis.2016.383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260875/
https://www.ncbi.nlm.nih.gov/pubmed/27882937
http://dx.doi.org/10.1038/cddis.2016.383

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