CD169(+) macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

Upon infection with persistence-prone virus, type I interferon (IFN-I) mediates antiviral activity and also upregulates the expression of programmed death ligand 1 (PD-L1), and this upregulation can lead to CD8(+) T-cell exhaustion. How these very diverse functions are regulated remains unknown. Thi...

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Detalles Bibliográficos
Autores principales: Shaabani, Namir, Duhan, Vikas, Khairnar, Vishal, Gassa, Asmae, Ferrer-Tur, Rita, Häussinger, Dieter, Recher, Mike, Zelinskyy, Gennadiy, Liu, Jia, Dittmer, Ulf, Trilling, Mirko, Scheu, Stefanie, Hardt, Cornelia, Lang, Philipp A, Honke, Nadine, Lang, Karl S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260878/
https://www.ncbi.nlm.nih.gov/pubmed/27809306
http://dx.doi.org/10.1038/cddis.2016.350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260878/
https://www.ncbi.nlm.nih.gov/pubmed/27809306
http://dx.doi.org/10.1038/cddis.2016.350

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