Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Doxorubicin (DOX) is one of the most effective antitumor drugs, but its cardiotoxicity has been a major concern for its use in cancer therapy for decades. Although DOX-induced cardiotoxicity has been investigated, the underlying mechanisms responsible for this cardiotoxicity have not been completely...

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Detalles Bibliográficos
Autores principales: Huang, Chih-Yang, Kuo, Wei-Wen, Lo, Jeng-Fan, Ho, Tsung-Jung, Pai, Pei-ying, Chiang, Shu-Fen, Chen, Pei-Yu, Tsai, Fu-Jen, Tsai, Chang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260882/
https://www.ncbi.nlm.nih.gov/pubmed/27809308
http://dx.doi.org/10.1038/cddis.2016.356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260882/
https://www.ncbi.nlm.nih.gov/pubmed/27809308
http://dx.doi.org/10.1038/cddis.2016.356

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