Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis

Serglycin is a proteoglycan that was first found to be secreted by hematopoietic cells. As an extracellular matrix (ECM) component, serglycin promotes nasopharyngeal carcinoma (NPC) metastasis and serves as an independent, unfavorable NPC prognostic indicator. The detailed mechanism underlying the r...

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Detalles Bibliográficos
Autores principales: Chu, Qiaoqiao, Huang, Hongbing, Huang, Tiejun, Cao, Li, Peng, Lixia, Shi, Simei, Zheng, Lisheng, Xu, Liang, Zhang, Shijun, Huang, Jialing, Li, Xinjian, Qian, Chaonan, Huang, Bijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260886/
https://www.ncbi.nlm.nih.gov/pubmed/27809309
http://dx.doi.org/10.1038/cddis.2016.287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260886/
https://www.ncbi.nlm.nih.gov/pubmed/27809309
http://dx.doi.org/10.1038/cddis.2016.287

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