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Lithium promotes DNA stability and survival of ischemic retinal neurocytes by upregulating DNA ligase IV
Neurons display genomic fragility and show fragmented DNA in pathological degeneration. A failure to repair DNA breaks may result in cell death or apoptosis. Lithium protects retinal neurocytes following nutrient deprivation or partial nerve crush, but the underlying mechanisms are not well defined....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260892/ https://www.ncbi.nlm.nih.gov/pubmed/27853172 http://dx.doi.org/10.1038/cddis.2016.341 |