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Lithium promotes DNA stability and survival of ischemic retinal neurocytes by upregulating DNA ligase IV

Neurons display genomic fragility and show fragmented DNA in pathological degeneration. A failure to repair DNA breaks may result in cell death or apoptosis. Lithium protects retinal neurocytes following nutrient deprivation or partial nerve crush, but the underlying mechanisms are not well defined....

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Detalles Bibliográficos
Autores principales:	Yang, Ying, Wu, Nandan, Tian, Sijia, Li, Fan, Hu, Huan, Chen, Pei, Cai, Xiaoxiao, Xu, Lijun, Zhang, Jing, Chen, Zhao, Ge, Jian, Yu, Keming, Zhuang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260892/ https://www.ncbi.nlm.nih.gov/pubmed/27853172 http://dx.doi.org/10.1038/cddis.2016.341

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