Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is involved in Alzheimer's neurodegeneration. However, the intrinsic link between E-NMDA...

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Detalles Bibliográficos
Autores principales: Sun, Xu-Ying, Tuo, Qing-Zhang, Liuyang, Zhen-Yu, Xie, Ao-Ji, Feng, Xiao-Long, Yan, Xiong, Qiu, Mei, Li, Shen, Wang, Xiu-Lian, Cao, Fu-Yuan, Wang, Xiao-Chuan, Wang, Jian-Zhi, Liu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260900/
https://www.ncbi.nlm.nih.gov/pubmed/27809304
http://dx.doi.org/10.1038/cddis.2016.329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260900/
https://www.ncbi.nlm.nih.gov/pubmed/27809304
http://dx.doi.org/10.1038/cddis.2016.329

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