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Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

N-methyl-d-aspartate receptors (NMDARs) are ion channels whose synaptic versus extrasynaptic localization critically influences their functions. This distribution of NMDARs is highly dependent on their lateral diffusion at the cell membrane. Each obligatory subunit of NMDARs (GluN1 and GluN2) contai...

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Detalles Bibliográficos
Autores principales: Lesept, Flavie, Chevilley, Arnaud, Jezequel, Julie, Ladépêche, Laurent, Macrez, Richard, Aimable, Margaux, Lenoir, Sophie, Bertrand, Thomas, Rubrecht, Laëtitia, Galea, Pascale, Lebouvier, Laurent, Petersen, Karl-Uwe, Hommet, Yannick, Maubert, Eric, Ali, Carine, Groc, Laurent, Vivien, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260909/
https://www.ncbi.nlm.nih.gov/pubmed/27831563
http://dx.doi.org/10.1038/cddis.2016.279