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Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box dom...
Autores principales: | Teixeira, Felipe Roberti, Randle, Suzanne J., Patel, Shachi P., Mevissen, Tycho E.T., Zenkeviciute, Grasilda, Koide, Tie, Komander, David, Laman, Heike |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260939/ https://www.ncbi.nlm.nih.gov/pubmed/27503909 http://dx.doi.org/10.1042/BCJ20160387 |
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