Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia

Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (A...

Descripción completa

Detalles Bibliográficos
Autores principales: Andresen, Vibeke, Erikstein, Bjarte S, Mukherjee, Herschel, Sulen, André, Popa, Mihaela, Sørnes, Steinar, Reikvam, Håkon, Chan, Kok-Ping, Hovland, Randi, McCormack, Emmet, Bruserud, Øystein, Myers, Andrew G, Gjertsen, Bjørn T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260983/
https://www.ncbi.nlm.nih.gov/pubmed/27906185
http://dx.doi.org/10.1038/cddis.2016.392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260983/
https://www.ncbi.nlm.nih.gov/pubmed/27906185
http://dx.doi.org/10.1038/cddis.2016.392

Ejemplares similares