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Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia

Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (A...

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Detalles Bibliográficos
Autores principales:	Andresen, Vibeke, Erikstein, Bjarte S, Mukherjee, Herschel, Sulen, André, Popa, Mihaela, Sørnes, Steinar, Reikvam, Håkon, Chan, Kok-Ping, Hovland, Randi, McCormack, Emmet, Bruserud, Øystein, Myers, Andrew G, Gjertsen, Bjørn T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260983/ https://www.ncbi.nlm.nih.gov/pubmed/27906185 http://dx.doi.org/10.1038/cddis.2016.392

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