Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells

Besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions. The possible therapeutic effects of BIBR1532 (BIBR), a powerful TERT inhibitor, have been evaluated in different cellular backgrounds, but no data...

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Detalles Bibliográficos
Autores principales: Celeghin, Andrea, Giunco, Silvia, Freguja, Riccardo, Zangrossi, Manuela, Nalio, Silvia, Dolcetti, Riccardo, De Rossi, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260987/
https://www.ncbi.nlm.nih.gov/pubmed/28032863
http://dx.doi.org/10.1038/cddis.2016.425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260987/
https://www.ncbi.nlm.nih.gov/pubmed/28032863
http://dx.doi.org/10.1038/cddis.2016.425

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