Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

The tumour suppressor p53 plays an important role in somatic cell reprogramming. While wild-type p53 reduces reprogramming efficiency, mutant p53 exerts a gain of function activity that leads to increased reprogramming efficiency. Furthermore, induced pluripotent stem cells expressing mutant p53 los...

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Detalles Bibliográficos
Autores principales: Grespi, Francesca, Landré, Vivien, Molchadsky, Alina, Di Daniele, Nicola, Marsella, Luigi Tonino, Melino, Gerry, Rotter, Varda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260988/
https://www.ncbi.nlm.nih.gov/pubmed/28032868
http://dx.doi.org/10.1038/cddis.2016.419

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