Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice

The apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some human malignancies. Caspase-2-deficient mice develop normally but show ageing-related traits and, when challenged by oncogenic stimuli or cert...

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Detalles Bibliográficos
Autores principales: Dawar, Swati, Shahrin, Nur Hezrin, Sladojevic, Nikolina, D'Andrea, Richard J, Dorstyn, Loretta, Hiwase, Devendra K, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260989/
https://www.ncbi.nlm.nih.gov/pubmed/27906175
http://dx.doi.org/10.1038/cddis.2016.406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260989/
https://www.ncbi.nlm.nih.gov/pubmed/27906175
http://dx.doi.org/10.1038/cddis.2016.406

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