A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

The intracellular distribution of a drug can cause significant variability in both activity and selectivity. Herein, we investigate the mechanism by which the anti-cancer agents, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and the clinically trialed, di-2-pyridylketone 4-cyclohexyl-...

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Detalles Bibliográficos
Autores principales: Seebacher, Nicole A, Richardson, Des R, Jansson, Patric J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261000/
https://www.ncbi.nlm.nih.gov/pubmed/27906178
http://dx.doi.org/10.1038/cddis.2016.381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261000/
https://www.ncbi.nlm.nih.gov/pubmed/27906178
http://dx.doi.org/10.1038/cddis.2016.381

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