Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models

Alzheimer's disease (AD) is characterized by synaptic and neuronal loss, which occurs at least partially through oxidative stress induced by oligomeric amyloid-β (Aβ)-peptide. Carnosic acid (CA), a chemical found in rosemary and sage, is a pro-electrophilic compound that is converted to its act...

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Detalles Bibliográficos
Autores principales: Lipton, Stuart A, Rezaie, Tayebeh, Nutter, Anthony, Lopez, Kevin M, Parker, James, Kosaka, Kunio, Satoh, Takumi, McKercher, Scott R, Masliah, Eliezer, Nakanishi, Nobuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261011/
https://www.ncbi.nlm.nih.gov/pubmed/27906174
http://dx.doi.org/10.1038/cddis.2016.389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261011/
https://www.ncbi.nlm.nih.gov/pubmed/27906174
http://dx.doi.org/10.1038/cddis.2016.389

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