Cargando…

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models

Alzheimer's disease (AD) is characterized by synaptic and neuronal loss, which occurs at least partially through oxidative stress induced by oligomeric amyloid-β (Aβ)-peptide. Carnosic acid (CA), a chemical found in rosemary and sage, is a pro-electrophilic compound that is converted to its act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lipton, Stuart A, Rezaie, Tayebeh, Nutter, Anthony, Lopez, Kevin M, Parker, James, Kosaka, Kunio, Satoh, Takumi, McKercher, Scott R, Masliah, Eliezer, Nakanishi, Nobuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261011/ https://www.ncbi.nlm.nih.gov/pubmed/27906174 http://dx.doi.org/10.1038/cddis.2016.389

Ejemplares similares

Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate
por: Satoh, Takumi, et al.
Publicado: (2017)

Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
por: Satoh, Takumi, et al.
Publicado: (2015)

MEF2C Enhances Dopaminergic Neuron Differentiation of Human Embryonic Stem Cells in a Parkinsonian Rat Model
por: Cho, Eun-Gyung, et al.
Publicado: (2011)

Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells
por: Chan, Shing Fai, et al.
Publicado: (2014)

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency
por: Nagar, Saumya, et al.
Publicado: (2017)

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
por: Satoh, Takumi, et al.
Publicado: (2022)

The Estimated Impact of Drug Importation, Mandatory Mail Service, and Medicaid Fee Reduction on Community Pharmacies in Michigan
por: McKercher, Patrick L.
Publicado: (2006)

S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
por: Sunico, Carmen R, et al.
Publicado: (2013)

Electrophiles against (Skin) Diseases: More Than Nrf2
por: Hennig, Paulina, et al.
Publicado: (2020)

Professional CUDA C programming
por: Cheng, John, et al.
Publicado: (2014)

Living on the edge
por: McKercher, Bob, et al.
Publicado: (2006)

The Over-Reaction to SARS and the Collapse of Asian Tourism
por: McKercher, Bob, et al.
Publicado: (2004)

Editorial: Special issue on CAUTHE 2021 conference
por: Scerri, Madalyn, et al.
Publicado: (2022)

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
por: Fagiani, Francesca, et al.
Publicado: (2020)

Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs
por: Zhang, Qing-Ye, et al.
Publicado: (2017)

Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads
por: Basagni, Filippo, et al.
Publicado: (2022)

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2015)

Do destinations have multiple lifecycles?
por: McKercher, Bob, et al.
Publicado: (2021)

Does the environment matter in the ‘new normal’?
por: Mkono, Mucha, et al.
Publicado: (2022)

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both
por: Akiyama, Masahiro, et al.
Publicado: (2019)

Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2016)

Associations of fish oil and vitamin B and E supplementation with cardiovascular outcomes and mortality in people receiving haemodialysis: a review
por: Bessell, Erica, et al.
Publicado: (2015)

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
por: Tu, Shichun, et al.
Publicado: (2017)

Erratum: Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both
por: Akiyama, Masahiro, et al.
Publicado: (2020)

Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress
por: Unoki, Takamitsu, et al.
Publicado: (2020)

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
por: Akhtar, Mohd Waseem, et al.
Publicado: (2016)

Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells
por: Tauber, Sarah, et al.
Publicado: (2021)

Electrophilic Selenium Catalysis with Electrophilic N-F Reagents as the Oxidants
por: Guo, Ruizhi, et al.
Publicado: (2017)

Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals
por: Poganik, Jesse R., et al.
Publicado: (2020)

Immunotherapy for Alzheimer’s disease: past, present and future
por: Spencer, Brian, et al.
Publicado: (2014)

Electrophilic Trapping of Semibenzenes
por: Boldrini, Cosimo, et al.
Publicado: (2022)

Reactivity of electrophilic cyclopropanes
por: Eitzinger, Andreas, et al.
Publicado: (2023)

Methods and Mechanisms for Cross-Electrophile Coupling of Csp(2) Halides with Alkyl Electrophiles
por: Weix, Daniel J.
Publicado: (2015)

Childhood and adolescent predictors of leisure time physical activity during the transition from adolescence to adulthood: a population based cohort study
por: Jose, Kim A, et al.
Publicado: (2011)

Copper-Catalyzed Electrophilic Chlorocyclization Reaction Using Sodium Chloride as the Source of Electrophilic Chlorine
por: Walter, Christopher, et al.
Publicado: (2019)

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis
por: Crews, Leslie, et al.
Publicado: (2009)

Role of Synucleins in Alzheimer’s Disease
por: Crews, Leslie, et al.
Publicado: (2009)

Electrophiles and acute toxicity to fish.
por: Hermens, J L
Publicado: (1990)

Electrophilic Trifluoromethylselenolation of Boronic Acids
por: Ghiazza, Clément, et al.
Publicado: (2017)

Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a S(N)Ar Reaction
por: Sánchez, Bruno, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a2ob91e44ul82ansdqjc2te4iu