Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling

In some cell types, activation of the second messenger cAMP leads to increased expression of proapoptotic Bim and subsequent cell death. We demonstrate that suppression of the cAMP pathway is a common event across many cancers and that pharmacological activation of cAMP in glioblastoma (GBM) cells l...

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Detalles Bibliográficos
Autores principales: Daniel, Paul M, Filiz, Gulay, Mantamadiotis, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261024/
https://www.ncbi.nlm.nih.gov/pubmed/27906173
http://dx.doi.org/10.1038/cddis.2016.393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261024/
https://www.ncbi.nlm.nih.gov/pubmed/27906173
http://dx.doi.org/10.1038/cddis.2016.393

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