The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability, potentially by preventing sodium (Na(+)) channel p...

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Detalles Bibliográficos
Autores principales: Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261566/
https://www.ncbi.nlm.nih.gov/pubmed/28118359
http://dx.doi.org/10.1371/journal.pone.0169882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261566/
https://www.ncbi.nlm.nih.gov/pubmed/28118359
http://dx.doi.org/10.1371/journal.pone.0169882

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