Cargando…

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Askew, Katharine, Li, Kaizhen, Olmos-Alonso, Adrian, Garcia-Moreno, Fernando, Liang, Yajie, Richardson, Philippa, Tipton, Tom, Chapman, Mark A., Riecken, Kristoffer, Beccari, Sol, Sierra, Amanda, Molnár, Zoltán, Cragg, Mark S., Garaschuk, Olga, Perry, V. Hugh, Gomez-Nicola, Diego
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263237/ https://www.ncbi.nlm.nih.gov/pubmed/28076784 http://dx.doi.org/10.1016/j.celrep.2016.12.041

Ejemplares similares

A new approach for ratiometric in vivo calcium imaging of microglia
por: Brawek, Bianca, et al.
Publicado: (2017)

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
por: De Lucia, Chiara, et al.
Publicado: (2016)

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
por: Sierra, Amanda, et al.
Publicado: (2014)

The Lifespan and Turnover of Microglia in the Human Brain
por: Réu, Pedro, et al.
Publicado: (2017)

Changing Functional Signatures of Microglia along the Axis of Brain Aging
por: Brawek, Bianca, et al.
Publicado: (2021)

Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
por: Plaza-Zabala, Ainhoa, et al.
Publicado: (2021)

Development and maintenance of the brain's immune toolkit: Microglia and non‐parenchymal brain macrophages
por: Lopez‐Atalaya, Jose P., et al.
Publicado: (2017)

Self-organized reactivation maintains and reinforces memories despite synaptic turnover
por: Fauth, Michael Jan, et al.
Publicado: (2019)

Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia
por: Olmedillas del Moral, Maria, et al.
Publicado: (2020)

Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
por: Mecha, Miriam, et al.
Publicado: (2020)

In-vivo RGB marking and multicolour single-cell tracking in the adult brain
por: Gomez-Nicola, Diego, et al.
Publicado: (2014)

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
por: Hu, Yanling, et al.
Publicado: (2021)

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
por: Diaz-Aparicio, Irune, et al.
Publicado: (2020)

Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia
por: Yu, Tao, et al.
Publicado: (2023)

Microglia and Brain Disorders: The Role of Vitamin D and Its Receptor
por: Mirarchi, Alessandra, et al.
Publicado: (2023)

Live imaging of microglia during sleeping sickness reveals early and heterogeneous inflammatory responses
por: Uzcategui, Nestor L., et al.
Publicado: (2023)

Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain
por: Diaz-Aparicio, Irune, et al.
Publicado: (2016)

A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis
por: Beccari, Sol, et al.
Publicado: (2017)

Microglia maintain the normal structure and function of the hippocampal astrocyte network
por: Du, Yixing, et al.
Publicado: (2022)

Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream
por: Meller, Sarah J., et al.
Publicado: (2023)

How to package and SEND mRNA: a novel “humanized” vector system based on endogenous retroviruses
por: Riecken, Kristoffer, et al.
Publicado: (2021)

Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction
por: Chew, Ting Gang, et al.
Publicado: (2017)

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
por: Holdgaard, Søs Grønbæk, et al.
Publicado: (2019)

Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb
por: Li, Kaizhen, et al.
Publicado: (2023)

Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope
por: Mirow, Manuela, et al.
Publicado: (2021)

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7
por: Silva, Susana L., et al.
Publicado: (2016)

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells
por: Micci, Luca, et al.
Publicado: (2014)

Erratum: Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
Publicado: (2021)

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
por: Plaza-Zabala, Ainhoa, et al.
Publicado: (2017)

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
por: Perry, V. Hugh, et al.
Publicado: (2013)

Plastid-Targeted Cyanobacterial Flavodiiron Proteins Maintain Carbohydrate Turnover and Enhance Drought Stress Tolerance in Barley
por: Shahinnia, Fahimeh, et al.
Publicado: (2021)

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
por: Liu, Feng, et al.
Publicado: (2023)

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain
por: Bedolla, Alicia, et al.
Publicado: (2023)

Arachidonic Acid Enhances Turnover of the Dermal Skeleton: Studies on Zebrafish Scales
por: de Vrieze, Erik, et al.
Publicado: (2014)

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
por: Chen, Xin, et al.
Publicado: (2011)

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge
por: O’Neil, Shane M., et al.
Publicado: (2018)

The role of NLRP3 inflammasome for microglial response to peripheral inflammation
por: Garaschuk, Olga
Publicado: (2020)

Understanding normal brain aging
por: Garaschuk, Olga
Publicado: (2021)

Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers
por: Möller, Johannes, et al.
Publicado: (2020)

Bone Marrow-Derived Mesenchymal Stem Cells Maintain the Resting Phenotype of Microglia and Inhibit Microglial Activation
por: Yan, Ke, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_e40e2nbmmdfi9gogh7qk0mps8f