Esterase mutation is a mechanism of resistance to antimalarial compounds

Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on the commercial source. Here we identify a minor contaminant (pepstatin butyl ester) as th...

Descripción completa

Detalles Bibliográficos
Autores principales: Istvan, Eva S., Mallari, Jeremy P., Corey, Victoria C., Dharia, Neekesh V., Marshall, Garland R., Winzeler, Elizabeth A., Goldberg, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263872/
https://www.ncbi.nlm.nih.gov/pubmed/28106035
http://dx.doi.org/10.1038/ncomms14240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263872/
https://www.ncbi.nlm.nih.gov/pubmed/28106035
http://dx.doi.org/10.1038/ncomms14240

Ejemplares similares