Divergent prion strain evolution driven by PrP(C) expression level in transgenic mice

Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrP(C) into PrP(Sc). Structurally distinct PrP(Sc) conformers can give rise to multiple prion strains. Constrained interactions between PrP(C) and different...

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Detalles Bibliográficos
Autores principales: Le Dur, Annick, Laï, Thanh Lan, Stinnakre, Marie-George, Laisné, Aude, Chenais, Nathalie, Rakotobe, Sabine, Passet, Bruno, Reine, Fabienne, Soulier, Solange, Herzog, Laetitia, Tilly, Gaëlle, Rézaei, Human, Béringue, Vincent, Vilotte, Jean-Luc, Laude, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264111/
https://www.ncbi.nlm.nih.gov/pubmed/28112164
http://dx.doi.org/10.1038/ncomms14170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264111/
https://www.ncbi.nlm.nih.gov/pubmed/28112164
http://dx.doi.org/10.1038/ncomms14170

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