Simvastatin promotes NPC1‐mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL‐loaded macrophages

Statins, 3‐hydroxyl‐3‐methylglutaryl coenzyme A reductase inhibitors, are the first‐line medications prescribed for the prevention and treatment of coronary artery diseases. The efficacy of statins has been attributed not only to their systemic cholesterol‐lowering actions but also to their pleiotro...

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Detalles Bibliográficos
Autores principales: Xu, Xiaoyang, Zhang, Aolin, Halquist, Matthew S., Yuan, Xinxu, Henderson, Scott C., Dewey, William L., Li, Pin‐Lan, Li, Ningjun, Zhang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264135/
https://www.ncbi.nlm.nih.gov/pubmed/27629819
http://dx.doi.org/10.1111/jcmm.12970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264135/
https://www.ncbi.nlm.nih.gov/pubmed/27629819
http://dx.doi.org/10.1111/jcmm.12970

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