HYDAMTIQ, a selective PARP‐1 inhibitor, improves bleomycin‐induced lung fibrosis by dampening the TGF‐β/SMAD signalling pathway

Idiopathic pulmonary fibrosis is a severe disease characterized by excessive myofibroblast proliferation, extracellular matrix and fibrils deposition, remodelling of lung parenchyma and pulmonary insufficiency. Drugs able to reduce disease progression are available, but therapeutic results are unsat...

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Detalles Bibliográficos
Autores principales: Lucarini, Laura, Durante, Mariaconcetta, Lanzi, Cecilia, Pini, Alessandro, Boccalini, Giulia, Calosi, Laura, Moroni, Flavio, Masini, Emanuela, Mannaioni, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264150/
https://www.ncbi.nlm.nih.gov/pubmed/27704718
http://dx.doi.org/10.1111/jcmm.12967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264150/
https://www.ncbi.nlm.nih.gov/pubmed/27704718
http://dx.doi.org/10.1111/jcmm.12967

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