WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

OBJECTIVE: Both excessive and insufficient activation of WNT signalling results in cartilage breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury and in osteoarthritis. Here, we investigate the function of WNT16 in osteoarthritis and the downstream molecular...

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Detalles Bibliográficos
Autores principales: Nalesso, Giovanna, Thomas, Bethan Lynne, Sherwood, Joanna Claire, Yu, Jing, Addimanda, Olga, Eldridge, Suzanne Elizabeth, Thorup, Anne-Sophie, Dale, Leslie, Schett, Georg, Zwerina, Jochen, Eltawil, Noha, Pitzalis, Costantino, Dell'Accio, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264226/
https://www.ncbi.nlm.nih.gov/pubmed/27147711
http://dx.doi.org/10.1136/annrheumdis-2015-208577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264226/
https://www.ncbi.nlm.nih.gov/pubmed/27147711
http://dx.doi.org/10.1136/annrheumdis-2015-208577

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