Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes

Dysregulation of lipid metabolism in skeletal muscle is involved in the development of insulin resistance. Mutations in lipin-1, a key lipid metabolism regulator leads to significant systemic insulin resistance in fld mice. However, the function of lipin-1 on lipid metabolism and insulin sensitivity...

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Detalles Bibliográficos
Autores principales: Huang, Shujuan, Huang, Suling, Wang, Xi, Zhang, Qingli, Liu, Jia, Leng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264256/
https://www.ncbi.nlm.nih.gov/pubmed/28123341
http://dx.doi.org/10.7150/ijbs.17149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264256/
https://www.ncbi.nlm.nih.gov/pubmed/28123341
http://dx.doi.org/10.7150/ijbs.17149

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