An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour

Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when associated with an intermolecular interaction...

Descripción completa

Detalles Bibliográficos
Autores principales: Motamedi-Shad, Neda, Jagger, Alistair M., Liedtke, Maximilian, Faull, Sarah V., Nanda, Arjun Scott, Salvadori, Enrico, Wort, Joshua L., Kay, Christopher W.M., Heyer-Chauhan, Narinder, Miranda, Elena, Perez, Juan, Ordóñez, Adriana, Haq, Imran, Irving, James A., Lomas, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264506/
https://www.ncbi.nlm.nih.gov/pubmed/27407165
http://dx.doi.org/10.1042/BCJ20160159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264506/
https://www.ncbi.nlm.nih.gov/pubmed/27407165
http://dx.doi.org/10.1042/BCJ20160159

Ejemplares similares