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Clusterin: full-length protein and one of its chains show opposing effects on cellular lipid accumulation

Proteins, made up of either single or multiple chains, are designed to carry out specific biological functions. We found an interesting example of a two-chain protein where administration of one of its chains leads to a diametrically opposite outcome than that reported for the full-length protein. C...

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Detalles Bibliográficos
Autores principales: Matukumalli, Suvarsha Rao, Tangirala, Ramakrishna, Rao, C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264606/
https://www.ncbi.nlm.nih.gov/pubmed/28120874
http://dx.doi.org/10.1038/srep41235