Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity

Idiosyncratic drug-induced hepatotoxicity is a major cause of liver damage and drug pipeline failure, and is difficult to study as patient-specific features are not readily incorporated in traditional hepatotoxicity testing approaches using population pooled cell sources. Here we demonstrate the use...

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Detalles Bibliográficos
Autores principales: Choudhury, Yukti, Toh, Yi Chin, Xing, Jiangwa, Qu, Yinghua, Poh, Jonathan, Huan, Li, Tan, Hui Shan, Kanesvaran, Ravindran, Yu, Hanry, Tan, Min-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264611/
https://www.ncbi.nlm.nih.gov/pubmed/28120901
http://dx.doi.org/10.1038/srep41238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264611/
https://www.ncbi.nlm.nih.gov/pubmed/28120901
http://dx.doi.org/10.1038/srep41238

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