PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions

Proliferating cell nuclear antigen (PCNA) is an essential cofactor for DNA replication and repair, recruiting multiple proteins to their sites of action. We examined the effects of the PCNA(S228I) mutation that causes PCNA-associated DNA repair disorder (PARD). Cells from individuals affected by PAR...

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Detalles Bibliográficos
Autores principales: Wilson, Rosemary H.C., Biasutto, Antonio J., Wang, Lihao, Fischer, Roman, Baple, Emma L., Crosby, Andrew H., Mancini, Erika J., Green, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264654/
https://www.ncbi.nlm.nih.gov/pubmed/28073635
http://dx.doi.org/10.1016/j.dnarep.2016.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264654/
https://www.ncbi.nlm.nih.gov/pubmed/28073635
http://dx.doi.org/10.1016/j.dnarep.2016.12.003

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