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Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC

Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic com...

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Detalles Bibliográficos
Autores principales: Khattar, Ekta, Tergaonkar, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266692/
https://www.ncbi.nlm.nih.gov/pubmed/28184371
http://dx.doi.org/10.3389/fcell.2017.00001