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Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation
Casitas B-lineage lymphoma-b (Cbl-b) is an E3 ubiquitin ligase that negatively regulates T cell activation. Cbl-b(−/−) T cells are hyper-reactive and co-stimulation independent, and Cbl-b(−/−) mice demonstrate robust T cell and NK cell-mediated antitumor immunity. As a result of these murine studies...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266705/ https://www.ncbi.nlm.nih.gov/pubmed/28184224 http://dx.doi.org/10.3389/fimmu.2017.00042 |